Consequently, PD patients with diabetes typically experience more severe motor symptoms and cognitive impairments
it is naturally occurring, nontoxic, and is active at a very low nanomolar concentration.11 Another piece of research described GHK-Cu as a safe, inexpensive, extensively studied compound.3 These conclusions primarily apply to topical GHK-Cu, but even with injectables, the lack of serious adverse events in animal subjects points to a general tolerability regardless of the route of administration
Aggregation rather than shear is the specific risk with an amylin-family sequence: the prolines at positions 25, 28 and 29 reduce fibrillation propensity relative to native amylin but do not eliminate it, so inspect the solution against a light source for haze, opalescence or filaments before use
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This remains speculative but merits caution