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3.2.2 Parkin ( PARK2 ) Parkin, encoded by PARK2 , is an E3 ubiquitin-protein ligase critical in protein homeostasis via monoubiquitylation, multiple monoubiquitylation, and K48-/K63-linked polyubiquitylation

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Hypoglycemic drugs such as metformin, SGLT2i, DPP-4i, GLP-1RA, anti-inflammation therapies, anti-senescence therapies, mineralocorticoid receptor antagonists, and stem cell therapies have also shown beneficial effects against tubular injury, potentially slowing the progression of the DKD, and thereby protecting the kidney