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Pro-inflammatory cytokines produced by adipose tissue support tumor-promoting intercellular crosstalk in the tumor microenvironment [14], thus enhancing tumor cell progression, angiogenesis, and invasion as essential requirements for metastasis [15]

O'Callaghan RM, Griffin EW, Kelly AM (2009)

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Research suggests that Epitalon may enhance lifespan, improve circadian rhythms, and exert antioxidant and anti-tumor effects

33,34 Hyperglycemia mediates a decrease in the expression of jund proto-oncogene subunit (JunD) and of free radical scavenger superoxide dismutase 1 and aldehyde dehydrogenase 2