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Whilst B12 is water-soluble and excess is excreted through urine, the liver stores substantial reserves lasting several years

In the mouse liver, NADH-reductive stress, whether induced by ethanol supplementation or expression of Ec STH, activates the transcription factor ChREBP (carbohydrate response element-binding protein), leading to transcription of metabolic programs associated with fatty liver 11

This allows the medication to disperse slightly and reduces the chance of it leaking back out through the needle track

It is important to note that this formulation of vitamin B complex is for veterinary purposes only

Endocrinology 150 , 33363344 (2009)