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Introduction Class B1 G-protein-coupled receptors (GPCRs) are activated by peptide hormones and neuropeptides that regulate essential physiological functions, including neuroprotection, bone turnover, cardiovascular tone, glycemic control, appetite, and energy balance (Bortolato et al., 2014)

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While lean mass typically accounts for about one-quarter of total weight lost, this pattern is comparable to other weight-loss approaches and not uniquely harmful

Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells

Blockade of IDO-kynurenine-ahR axis ameliorated colitis-associated colon cancer via inhibiting immune tolerance