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The gut-brain axis, a bidirectional communication network between the gastrointestinal tract and the central nervous system, integrates these peripheral signals with the central appetite effects to produce comprehensive appetite suppression

While slightly less effective at inducing weight loss than the Wegovy pill, trials have suggested that orforglipron could be used as a long-term weight maintenance option for those who have lost weight with GLP-1 injections

Most weight loss will typically occur within the first 4 to 5 months

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