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For semaglutide specifically, patients with kidney dysfunction do not require renal dosing adjustments (Key Considerations in Use of SGLT2 Inhibitors and GLP-1RAs for CV Risk Reduction in Patients with T2D, 2020) Contraindications to GLP-1 agonists include a history of serious hypersensitivity reactions to a GLP-1 agonist, pregnancy, breastfeeding, and a personal or family history of medullary or thyroid cancer or MEN2 (Key Considerations in Use of SGLT2 Inhibitors and GLP-1RAs for CV Risk Reduction in Patients with T2D, 2020)

Certain studies have shown that even two days of significant calorie deprivation can have robust effects on mood

Semaglutide improves cognitive function and neuroinflammation in APP/PS1 transgenic mice by activating AMPK and inhibiting TLR4/NF-B pathway

Case Report: Semaglutide-associated depression: a report of two cases

Physical changes often become more noticeable at this stage, such as feeling lighter, seeing a lower number on the scales, or finding that your clothes fit more loosely