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If your cholesterol doesn't improve as expected, your genetic profile may indicate a weaker response to GLP-1 and GIP signaling, or other factors (diet, exercise, genetics) may be limiting the effect

if patients have not achieved at least 5% weight loss, discontinuation should be considered

Losing 20 kg of pure fat while maintaining all your muscle mass produces a dramatically different health outcome than losing 15 kg of fat and 5 kg of muscle