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Serotonin syndrome can be fatal, which is why doctors dont use methylene blue along with medications that include or increase serotonin, such as certain antidepressants

The regulators are setting them in the real world all the time

Nitrosylation of Cys145 by nitrosoglutathione (GSNO) inactivates MGMT, leading to its ubiquitination and proteasomal degradation and reducing its half-life from 24 to 1.3 h

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