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M.PicardM.OhlssonL.BersaniF

In the Phase 2 trial, the cohorts that escalated to higher maintenance doses began at 2mg weekly and increased by 2mg every 4 weeks

investigated -MSH-derived peptides including KPV for their anti-inflammatory properties and inhibition of NF-B-dependent cytokine pathways

Injectable routes carry a particular concern for immunogenicity from peptide aggregation and impurities, and FDA noted the available certificates of analysis for AOD-9604 bulk drug substances did not consistently control for impurities, aggregates, or microbial limits

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