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Rapid or excessive weight loss can increase the risk of gallstones, loss of muscle mass and bone density, and nutritional deficiencies. Some people, including older adults, postmenopausal women, and individuals whose weight loss approaches a range considered underweight may be at particularly increased risk for negative health impacts from rapid or excessive weight loss, Moiz says

Previous studies have also reported that feeding Apoe (/) mice with tocopherols and tocotrienols downregulated the expression of CD36 and upregulated the transcriptional activity of LXR , ABCA1 , and peroxisome proliferator-activated receptor gamma ( PPAR ) (Tang et al., 2014)

doi:10.1590/S1415-47572013000100005