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257 In GLP-1R KO mice, the distal gut was found to display microbial dysbiosis and was more sensitive to inflammation-related injury, which was thought to be due to dysregulated inflammation-related gene expression

[3],[4] In addition, the traditional role of metformin in the early management of T2D is not always appropriate if not tolerated or contraindicated (eg, eGFR 20-25 mL/min/1.73 m 2

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Potential for Acromegaloid Features at Excessive Doses Chronic supraphysiologic IGF-1 levels can mimic growth hormone excess

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