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In brief, berberine can reduce anti-apoptotic factors (Bax/bcl-2, caspase), autophagy related proteins (IL-3, Beclin, etc.), A pathology, and activate PI3K-AKT and other signaling pathways, and then produce neuroprotective effect (Figure 1)

Resolution of NASH and hepatic fibrosis by the GLP-1R/GCGR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis

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