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Dihexa was synthesized as a small molecule compound that, in in vitro studies, demonstrated its ability to induce spinogenesis and synaptogenesis at picomolar concentrations

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The ARC may exert its effects on energy homeostasis by direct cortical projections or indirectly via second order neurons in adjacent hypothalmic nuceli of which the paraventricular nucleus (PVN) is believed to be play a crucial role[62,63]