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The impact of integrase inhibitors on steatosis and fibrosis biomarkers in persons with HIV nave to antiretroviral therapy

In preclinical research, its applied to cultured fibroblasts, keratinocytes, and endothelial cells to study extracellular matrix modulation , antioxidant defenses , and microvascular formation

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(PubMed) Pettegrew JW, Klunk WE, Panchalingam K, Kanfer JN, McClure RJ

Patients on Tasigna often need to adhere to strict fasting before taking the drug to avoid these toxicities