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SGLT2 Inhibitors: A Game-Changer in Heart Failure and Kidney Disease The story of Sodium-Glucose Cotransporter-2 (SGLT2) inhibitors is one of the most exciting developments in modern medicine

However, GEP44 has a superior therapeutic window, as rats could be treated with higher doses (up to 100 nmol/Kg/d) with no notable adverse effects

There is little reason to believe that GLP1R agonists are somehow specifically targeting only autoimmune cells, while sparing the rest since molecularly there is no reason for only autoimmune cells to express GLP1R, but for other normal immune cells to not express GLP1R

They stimulate fibroblasts to produce new collagen and elastin, thicken the dermis and restore elasticity