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In comparison to the wild type mice, APP/PS1 mice experienced significant synaptic loss as well as a reduction in the number of neuronal cells in the cerebral cortex

Nutritional status can modulate these signaling pathways by influencing the availability of cofactors and substrates required for enzyme activity and protein synthesis

Xiong, X., Cheng, Z., Wu, F., Hu, M., Liu, Z., Dong, R., & Chen, G

This is critical context: NAD+ IV causes transient vasodilation and smooth muscle effects that can range from mild warmth to significant discomfort