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New England Journal of Medicine , 375(19), 18341844

[1] Dehydration from gastrointestinal side effects can increase the risk of acute kidney injury

Finally, a number of inherited mutations in genes involved in carnitine shuttling and fatty acid oxidation pathways do not systematically result in carnitine depletion (such that carnitine supplementation may not help mitigate the symptoms) but lead to abnormal profiles of acylcarnitine esters in blood (35, 40)