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Additionally, Zepbound (tirzepatide) received approval for obstructive sleep apnea (OSA) in adults with obesity in 2024, marking the first FDA-approved pharmacotherapy for OSA

Gastroparesis occurs when the stomach is slow to empty, which can be an effect of the active ingredient in Ozempic and Wegovy, which benefits diabetes and weight loss patients by making them feel full longer after eating

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For contextual class comparisons, the eMC SmPCs for semaglutide (Wegovy/Ozempic) and tirzepatide (Mounjaro) provide authoritative information on hypersensitivity and injection site reactions associated with approved GLP-1-based agents, and are relevant reference points for clinicians managing similar symptoms in patients receiving retatrutide in a trial setting

Type 2 diabetes is the most common type internationally, accounting for an estimated 90 to 95 percent of all diabetes cases in the United States alone2