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Globally, diabetes has reached epidemic proportions with an estimated 537 million adults affected by 2021 ( [25] )

But heres what we know from recent research: A 2025 study presented at ENDO showed that postmenopausal women using tirzepatide plus hormone replacement therapy (HRT) lost significantly more weight (17% total body weight) compared to women using tirzepatide alone (14%)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Fiorentino TV, Casiraghi F, Davalli AM, et al (2019) Exenatide regulates pancreatic islet integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas

Under-eating is one of the biggest hidden causes of GLP-1 fatigue