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The procedures of animal study were approved by the Institutional Animal Care and Use Committee (IACUC2017O04) of National Laboratory Animal Center, National Applied Research Laboratories, Taiwan

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This enhanced potency explains why semaglutide produces greater weight loss at lower relative doses

AMPK also serves a role in regulating lipid and protein metabolism by inhibiting the generation of transcription factors that bind to sterol regulatory elements, suppressing the synthesis of lipid biosynthetic enzymes in tissues, inhibiting fat synthesis, increasing fatty acid oxidation and reducing lipid accumulation (173)

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