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L., Vilsboll, T

On one side, this signaling axis could explain the beneficial effects mediated by exercise and caloric restriction in young mice and, on the other side, it could represent a target for determining the adaptive response of skeletal muscle under aging or pathological conditions

confounding factors such as underlying health conditions are likely to play a role

Nrf2 is then translocated to the nucleus, forms heterodimers with other transcription factors such as c-Jun and small Maf proteins (G/F/K), binds to the electrophile response element (EpRE) (also known as the antioxidant response element) in the promoters of GCLC and GCLM, and regulates gene transcription

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