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Its impact on DPN is thought to be more significant when utilized in conjunction with standard treatments (such as gliclazide, SGLT2 inhibitors, metformin, and GLP-1 analogs) for patients with T2DM who are experiencing neuropathic pain [209]

Adding further complexity, GLP-1RAs can stabilize the BBB (219, 220), raising the possibility that drugs with limited baseline uptake may improve their own CNS access over time, particularly in aging or NDD states where BBB dysfunction is common

Patent 4,599,232.Dura Carn is a registered trademark of Sigma-Tau Health Science, Inc