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118 In a double-blind, placebo-controlled trial of 60 mechanically ventilated patients at high risk of developing ventilator-associated pneumonia (VAP), NAC significantly reduced the risk of VAP versus placebo, 26.6% versus 46.6%, and shortened intensive care unit (ICU) stay (14.4 versus 17.8 days) and hospital stay (19.2 versus 24.6 days)
Blood 111 , 37933801, doi: 10.1182/blood-2007-07-104042 (2008)
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as a result, surfactant production decreases markedly, which in turn causes alveolar fluid accumulation leading to alveolar collapse and ARDS (Matthay and Zemans, 2011
The dose of BAY11-7082 was chosen based on our preliminary results of dose response, which showed that 10 M BAY11-7082 significantly increased the number of surviving SGNs after cisplatin damage in vitro (Supplementary Figure 2)
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