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Mechanistically, autocrine IGF-2 promotes self-activation by binding to the IGF-1 receptor (IGF-1R) on CAFs and activating PI3K/AKT signaling, followed by the secretion of various chemokines and cytokines (CCL5 and CXCL12) by CAFs to influence the infiltration of T cell

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This phenomenon is independent of DPP-IV, the GLP-1 receptor, or the PYY related peptide NPY

They enhance glucose-dependent insulin secretion, suppress glucagon release, delay gastric emptying, and reduce appetite, thereby contributing to glucose homeostasis and body weight regulation (29, 30)

Once opened, store at 28C and discard any unused portion after 28 days of first use