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The key advantage of this mechanism compared to exogenous GH administration is preservation of normal physiological regulation: tesamorelin stimulates GH release but the body's negative feedback systems (mediated by IGF-1, somatostatin, and other factors) remain functional, preventing excessive or sustained GH elevations

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A: Multiple pathways: GH receptor upregulation, nitric oxide system modulation, VEGF-promoted angiogenesis, and direct inflammatory cytokine interaction

Pyo HK, Yoo HG, Won CH, Lee SH, Kang YJ, Eun HC, Cho KH, Kim KH

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