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GLP-1 drugs may be prescribed for the following conditions as per American Diabetes Association/European Association for the Study of Diabetes (ADA/EASD) 2025 guidelines 11 : Primary glycaemic indication: GLP-1 RAs are recommended for adults with type 2 diabetes who have not reached their individualised A1C targets (typically when A1C is 1.5% above the agreed glycaemic goal) despite lifestyle measures and foundational therapy such as metformin

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Weight management medication may be considered for adults with obesity or certain adults who are overweight and also have weight-related health concerns

The study enrolled 407 patients with an average age of 56 to evaluate the effects of semaglutide use on knee pain