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The major reason as to why maintaining a healthy cellular glutathione (GSH) level is so critical for the immune system is related to the fact that lymphocytes perform their bacterial, viral and cancer cell killing functions by generating large amounts of ROS including superoxide and hydrogen peroxide

In HCC, AKR1C3 has been implicated in resistance to sorafenib, a targeted therapy used in the treatment of HCC

They are an economically, biotechnologically, and nutritionally valued group of organisms because of their importance in medicines, biocontrol, food, and the biological, chemical, cosmeceutical, and various other industries

Factors include condition-specific responses, patch material, cell type, individual health, and age

JP patent 60,160,894 Acknowledgements The authors thank Dr