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This causes a self-perpetuating cycle of damage.* The cell maintains efficiency through a natural response called mitophagy
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GHK-Cu RNA-seq analysis shows GHK-Cu upregulates genes associated with synaptic plasticity, BDNF signalling, and neurogenesis, while downregulating genes associated with neuroinflammation and amyloid processing
341,342,343,344 Correspondingly, astroglial GLT1 and glutamate uptake is significantly reduced in the cortex in fmr1 / mice, which may explain the enhanced neuronal excitability observed in mice with fragile X syndrome