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Even in these studies including patients without overweight or obesity, significant weight loss was observed

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The glucagon receptor mechanism facilitates energy expenditure and fat oxidation, contributing to significant weight reduction

In mammals hepcidins share no significant sequence homologies to any of the known antimicrobial peptides, but they resemble structurally some insect defensins and defensin-like drosomycin (from Drosophila melanogaster ) [155, 156]