Due to putative importance of the exendin-4 C-terminus, it is conceivable that the lixisenatide-specific changes could affect its pharmacology
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Ma, X., Liu, Q
46,47 In addition, the CTD is necessary for contact with negative regulators (MDM2/4) and to induce many posttranslational modifications, such as acetylation, phosphorylation, methylation, and ubiquitination, which adjust its functionality and stability
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