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Semaglutide nausea tends to be more constant and less tied to eating, while tirzepatide nausea often intensifies after meals

In the multiple-dose trial, eligible subjects were healthy males, aged 1864 years, with a BMI of 20.029.9 kg/m 2 , and males with T2D diagnosed within the last 10 years, treated with diet and exercise and/or metformin, aged 1864 years, with a BMI of 20.037.0 kg/m 2 and glycosylated haemoglobin (HbA 1c ) of 6.59.0%

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It is contraindicated in anyone with a personal or family history of medullary thyroid carcinoma (MTC) or with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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