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In this context, the intranasal route has emerged as a promising solution for delivering treatments directly from the nose to the brain through the olfactory and trigeminal nerve pathways and thus, bypassing the BBB

GHK-Cu stimulates the fibroblasts in the skin, which are responsible for producing collagen

-syn can be degraded via the ubiquitin-proteasome system and autophagy/lysosomal pathways, but protein clearance is impaired in PD, resulting in abnormal protein accumulation

While some studies demonstrate benefits in stroke recovery and vascular dementia, large-scale trials (particularly CASTA) failed to show superiority over placebo in primary outcomes

They actually rebuild collagen stores over time, producing progressive improvement rather than mere maintenance of current state