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The Semaglutide Treatment Effect in People with obesity (STEP) program, a phase III randomized clinical trial (RCT), was conducted in patients with T2D, obesity, and various metabolic disorders

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Additionally, it has an antioxidant, detoxifying and protective effect on blood vessels

It would also help explain a clinical observation discussed later: the gastrointestinal side effects associated with amylin analogs (nausea, early fullness) tend to be most pronounced during dose escalation and to ease with continued treatment, a pattern consistent with partial adaptation of the very gastric mechanism in question

Further 2025 reviews highlight its safety and efficacy in improving insulin sensitivity in overweight, insulin-resistant cohorts (439)