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To assess the nanotoxicity in a complex way, all-inclusive hemocompatibility testing, which includes assessment of hematocrit, hemostasis, nano-cell interactions, immunotoxic effects, etc., is recommended [448]

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RF microneedling is considered safer and more predictable for melanin-rich skin tones than ablative laser approaches, and combining it with GHK-Cu addresses both the structural deficit and the inflammatory component that often drives post-inflammatory hyperpigmentation in these patients