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The energy expenditure effects contribute to Retatrutide's superior weight loss efficacy compared to GLP-1-only therapies

One of the major limitations of this study, however, there is lack of evidence of direct linkage of the proposed biomarkers with complications of diabetes (e.g., longitudinal follow-up study), which is important evidence base towards clinical utility of the proposed biomarkers

Treatment plans are tailored following consultation

Neither one rescues a broken one

Abbreviations GLP-1RAs: Glucagon-like peptide-1 receptor agonists AF: Atrial fibrillation GWAS: Genome-wide association study cis-eQTLs: cis-expression quantitative trait loci OR: Odds ratio CI: Confidence interval T2DM: Type 2 diabetes mellitus MR: Mendelian randomization SNPs: Single nucleotide polymorphisms RCTs: Randomized clinical trials BMI: Body mass index ICD: International Classification of Diseases IVW: Inverse-variance weighted MR-PRESSO: Mendelian Randomization Pleiotropy RESidual Sum and Outlier MVMR: Multivariable Mendelian randomization PP.H4: Posterior probability of hypothesis 4 CAD: Coronary artery disease References Rawshani A, Rawshani A, Franzn S, Eliasson B, Svensson AM, Miftaraj M, et al