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The studies show that when women with obesity lose weight with semaglutide, they improve their body composition with reduced waist circumference, indicative of less visceral fat, and they also reduce their risk of heart attacks and strokes while improving their quality of life, from migraine burden to depression and menopause symptoms

The combination group had the best effect, with cartilage close to normal

By September 2025, the FDA had issued more than 50 warning letters to GLP-1 compounders and manufacturers with confirmed DOJ involvement, and 40-plus state attorneys general formally petitioned the FDA about counterfeit peptides entering the US market

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