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Discussion Our concept, which we verified in several previous paper [24, 32, 33, 42], is that if we mimic the specific expression pattern of nutrient transporters at the BBB with a combination of two or three different ligands a more specific targeting of nanoparticles across the BBB can be achieved

Sex distribution and mean age are also listed for each brain region based on diagnosis group (as the number of participants collected varied for each brain region

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By overcoming the challenges of direct administration, such as systemic toxicity and patient compliance issues (109), this technology holds significant promise for improving RA management