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the PK-PD disconnect supports this

Another randomized controlled trial showed that soybean isoflavone therapy (80 mg/day, P.O for 24 weeks) significantly increased the protein and mRNA levels of Nrf2 and the concentrations of SOD as well as diminished serum levels of inflammatory factors and MAD in patients with myocardial ischemia [139]

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These were tested first in the statistical testing hierarchy, followed by the confirmatory secondary endpoints, which were tested in the following order: achievement of weight loss of at least 10% or 15% at week 104

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