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?Glutamate plays key roles linking carbohydrate and amino acid metabolism via the tricarboxylic acid (TCA) cycle, as well as in nitrogen trafficking and ammonia homeostasis in the brain.?During oxidative stress, disruptions in reactive oxygen species(ROS) clearance impair glutamate homeostasis, leading to excitotoxicity and neuronal damage

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Arroyo E, Valdez R, Cornejo-Bravo J, Armenta M, Olivas A