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Here are the most common reasons people feel tired while taking tirzepatide: You May Be Eating Less Tirzepatide reduces appetite and helps you feel full faster, which can make it easy to under-fuel without realizing it

FDA Prescribing Information Mounjaro (Tirzepatide) injection Prescribing Information

Mitigating side effects Many pharmacies and clinics claim that niacinamide may help reduce certain gastrointestinal side effects of tirzepatide, such as nausea

Many patients at higher doses switch to a 30 mg/mL concentration specifically to avoid this issue

Some people achieve their weight loss goals on a 5 mg or 10 mg dose, while others may need to go up to the maximum dose