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With respect to cell death, induction of p21 FL modestly delayed the onset of erastin2-induced death alone, and to a greater extent when combined with nutlin-3, consistent with an independent requirement for both p53 and p21 in the suppression of ferroptosis (Fig 2F)

Phase 2 trial in type 2 diabetes (Lancet 2023) also showed superior weight loss for the combination versus either monotherapy

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Getting into the eye, drops help maintain the balance of the flow and outflow of eye fluid