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Important safety considerations include: Increased risk of hypoglycaemia when used with insulin or sulfonylureas (dose adjustments may be required) Not recommended in patients with severe gastrointestinal disease, including severe gastroparesis Potential worsening of diabetic retinopathy, particularly in patients with a history of this condition Reduced efficacy of oral contraceptives due to delayed gastric emptying (non-oral contraception or additional barrier methods are recommended for 4 weeks after initiation and after each dose increase) The prescribing of Mounjaro in the UK follows guidance from the Medicines and Healthcare products Regulatory Agency (MHRA) and National Institute for Health and Care Excellence (NICE)

PDA and BPC-157 share the exact same fifteen amino acids in the exact same order

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