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Between February 2024 and October 2025, the number of American adults who reported taking GLP-1s for weight loss more than doubled, constituting roughly 12% of the population, according to Gallup polling

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For general wellness and maintenance, monthly is often enough

[5] [6] The STEP trials evaluating semaglutide for weight management showed similar patterns, with gastrointestinal adverse events being the primary reason for treatment discontinuation in a small percentage of participants