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doi: 10.4103/JCRT.JCRT_862_16

A body composition substudy of the Phase 2 diabetes trial, published in The Lancet Diabetes & Endocrinology in 2025, used DXA scans to measure changes in fat and lean mass in 189 participants

This test involves an overnight fast

Combine this with the metabolic stress of rapid weight loss, and many men experience significant drops in testosterone that manifest as fatigue, loss of libido, mood disturbances, and accelerated muscle loss