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For instance, erastin and RSL3 selectively affects the glutathione antioxidant system, which leads to increase lipid peroxidation and causes the death of cancer cells [29, 87]

Importantly, drug-resistant tumor are more sensitive to lipid peroxidation, which undoubtedly makes, the combination of System X c /GSH/GPX4 axis-based ferroptosis inducers with chemotherapeutic agents may become a new strategy for the treatment of drug-resistant solid tumors (Viswanathan et al., 2017)