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IAA can also promote tumor growth in some cases (e.g., in renal and esophageal cancer cells), for example, by inducing Ahr in macrophages and Teffs, suppressing antitumor immunity [133]

Biomedicine & Pharmacotherapy , 57(34), 145155

As both H 2 O 2 and BCNU exposure led to excessive cellular GSSG accumulation, their impact on intracellular protein-GSSG adduct formation (protein S -glutathionylation) was subsequently examined in HepG2 cells by western blot analysis using a monoclonal GSSG antibody that specifically binds to GSSG-modified proteins

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GPX1 (Glutathione Peroxidase, GSHPx) Gene Variants and Cardiovascular Disease Introduction The GPX1 gene , also known as GSHPx , encodes glutathione peroxidase 1 , a selenium-dependent enzyme critical for detoxifying peroxides and reducing oxidative stress