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Patients on this combination have reported tachycardia, hypertension spikes, and arrhythmia concernsside effects that existing clinical trials were not designed to assess

More serious but rare risks include pancreatitis, gallbladder disease, intestinal obstruction, acute kidney injury from dehydration, and potential thyroid concerns

Most critically, while the mechanistic and preclinical foundation is strong, clinical studies in humans would be required to establish optimal dosing, administration schedules, safety profiles, and actual synergistic effects for this specific combination

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If exercise seems to cause extra beats, you may be at a higher risk of other heart rhythm problems