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*Correspondence: Raffaele Palmirotta [email protected] This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

doi: 10.1016/j.tips.2018.06.004 129 LiuZIyerMRGodlewskiGJourdanTLiuJCoffeyNJ

For more severe cases, systemic medications may be prescribed

Importantly, the cytokine transduces a pro-inflammatory signal from the periphery to the CNS through endothelial cells of the bloodbrain barrier [75, 76]

Neither cagrilintide nor retatrutide is FDA approved as of early 2026