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SARS-CoV-2 infection generates massive ROS production and the excessive oxidative damage is responsible for cytokine storm, undermined immunity, tissue damage and severe lung disease causing ARDS and death (Silvagno et al., 2020)

It doesnt cause any long-term deficits. He also adds that contrary to Hubermans description, it doesnt shut down the hippocampus,' a component of the brain important for memory functions

It is involved in several biochemical processes, including detoxification, immune response, and cellular repair

doi: 10.1080/15216540152845957

Moreover, the activation of Sirtuin-1 can promote Parkin to translocate from cytosol into OMM, while inhibition of Sirtuin-1 reverses these effects ( 3.3.1.1 Polydatin Polydatin, a resveratrol glycoside isolated from traditional Chinese herb, Polygonum cuspidatum ( via the activation of Sirtuin-1